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一抹詭魅微笑…隨時索命勾魂！精神科醫生露絲（蘇絲貝根飾）目睹病人面帶詭異笑容在她面前自殺，自此彷彿受到詛咒，接連碰上難以解釋的可怕遭遇。當露絲的生命逐漸被這股強大的恐懼力量侵蝕，她意識到必須面對充滿創傷的過去，才能找出活命方法，逃離令她惶恐窒息的現實。

After witnessing a bizarre, traumatic incident involving a patient, Dr. Rose Cotter starts experiencing frightening occurrences that she can't explain. Rose must confront her troubling past in order to survive and escape her horrifying new reality.